Active ingredient

Milbemectin

Description

Milbemectin is a highly effective active ingredient belonging to the macrocyclic lactone chemical class. It is derived from the natural fermentation products of the soil-dwelling bacterium Streptomyces hygroscopicus. Due to its biological origin, it is widely recognized as an environmentally compatible tool for managing various agricultural pests.

This compound primarily serves as a powerful acaricide and insecticide with both contact and stomach action. It is specifically designed to combat various species of spider mites, rust mites, and other phytophagous mites. Furthermore, it demonstrates secondary efficacy against insects like thrips, aphids, and leafminers, making it a versatile asset in integrated pest management programs.

The mode of action of Milbemectin involves binding to glutamate-gated chloride channels in the nervous system of pests. This interaction disrupts nerve transmission, leading to immediate paralysis and cessation of feeding. A significant advantage is its activity against all life stages of mites, including eggs, which prevents the rapid resurgence of pest populations.

Milbemectin is suitable for use on a wide variety of crops, including fruits, vegetables, and ornamentals grown in greenhouses or open fields. It possesses translaminar activity, meaning the compound penetrates the leaf tissue to protect the underside of the foliage. This property ensures long-lasting control even when direct coverage is difficult to achieve.

  • Effective control of eggs, nymphs, and adults.
  • Excellent translaminar movement within plant tissues.
  • Long residual activity, often lasting several weeks.
  • Reduced impact on many beneficial predator insects.
  • Proven solution to combat resistance in mite populations.

When applying Milbemectin, it is essential to follow standard safety precautions to protect both the operator and the environment. Operators should wear appropriate protective clothing, gloves, and respiratory protection during mixing and spraying. It is crucial to respect the pre-harvest interval (PHI) to ensure that the produce is safe for consumer consumption and adheres to regulatory standards.

Regulatory

Status in the European Union

Approved in the EU

CAS number
See note
Category (EU)
IN - Insecticide
Approved from
16.11.2025
Approval until
15.11.2040
ADI
0.007 mg/kg bw/day
ARfD
0.03 mg/kg bw
AOEL
0.014 mg/kg bw/day
Hazard classification (CLP)
Acute Tox. 4 - H302Acute Tox. 4 - H332Aquatic Acute 1 - H400Aquatic Chronic 1 - H410

Regulatory status data: EU Pesticides Database © European Union, CC BY 4.0. EU status is for reference only and does not replace national registration in your country.

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